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This guideline is the first comprehensive evidence-based guideline to address treatment of the pain of sickle-cell disease.

Authors

• Lennette J. Benjamin, MD
• Carlton D. Dampier, MD
• Ada Jacox, PhD RN
• Victoria Odesina, MS RN
• David Phoenix, PhD
• Barbara S. Shapiro, MD
• Maureen Strafford, MD
• Marsha Treadwell, PhD

Contents

Overview of Sickle-Cell Disease and Related Pain

Types and Characteristics of Pain Associated with Sickle-Cell Disease

Pain Assessment

Treatment of Pain in Sickle-Cell Disease

Pharmacological Management of Sickle Pain

Acetaminophen and NSAIDs

Opioids: Side Effects, Tolerance, Physical Dependence and Addiction

Drugs

Management of an Episode of Acute Pain

Details of Opioid Administration

Psychological, Behavioral, and Physical Interventions

Importance of Comprehensive Care

Sickle Pain in Developmental Stages

Focus of Care in Various Settings