Spring Pain 2015
May 11-13, 2015
Palm Springs, CA
The Spring Pain meeting is back! Be the first to hear presentations of original, not-yet published research. Participate in informative talks on hot topics in sensory research. Enjoy fun activities with colleagues each afternoon.
This year, APS will handle Spring Pain registration. Spring Pain attendees who also register for the APS Annual Scientific Meeting will save $50 on their Spring Pain registration. Note: the $50 discount is for Spring Pain registration, not for Annual Scientific Meeting registration.
Additional details regarding Spring Pain sessions can be found at www.springpainconference.com.
Spring Pain Golf Outing – Tuesday, May 12
Join your Spring Pain colleagues for an afternoon of golf at the Escena Golf Club in beautiful Palm Springs. Tee-time is 2:02 pm. Cost is $45 for person and $25 to rent clubs. Contact Michael Jankowski to reserve your spot. Space is limited. Taxi fares from the Renaissance Hotel to the golf course is about $12.
Monday, May 11
4 pm
Welcome
4:05-5 pm
Session 1–Preclinical Use of Human Tissue
Chair: Robert Gereau
Robert Gereau, Washington University-St Louis
Human sensory neurons: characterization of firing properties, sensitization, and a test case of translational potential
Michael Gold, University of Pittsburgh
Human DRG Neurons: An Essential Preclinical Screen?
Brian Wainger, Massachusetts General Hospital
Pain in a Dish: Modeling with Derived Nociceptors
Lori Birder, University of Pittsburgh
Human uro-epithelium: offering bench-to-bedside target validity
5-6 pm
Session 2–Non-neuronal Contributions to Pain
Chair: Gregory Dussor
Jianguo Gu, University of Alabama-Birmingham
A Whisker Hair Tells a Touchy Tale: Tactile Transduction and encoding in mammals
Ru-Rong Ji, Duke University
Astrocyte signaling in chronic neuropathic pain
Gregory Dussor, University of Texas-Dallas
Meningeal fibroblasts and the pathophysiology of headache
Kathleen Sluka, University of Iowa
Resident Macrophages Expressing P2X4 Mediate Exercise-Induced Pain
6:30–8 pm
Welcome Reception
Tuesday, May 12
8-9 am
Session 3–Mechanisms of Latent Sensitization
Chair: Bradley Taylor
Bradley Taylor, University of Kentucky
Adenylyl cyclase 1 drives chronic pain vulnerability
Juan-Carlos Marvizon, University of California, Lose Angeles
Latent Sensitization: involvement of descending signals and stress
Stephen Bruehl, Vanderbilt University
A Tool for Studying Endogenous Opioid Mechanisms in Human Latent Sensitization
Simon Beggs, University of Toronto
Long-term consequences of neonatal injury
9-9:45 am
Session 4–Pediatric Pain
Chair: Michael Jankowski
Michael Jankowski, University of Cincinnati
Growth Hormone and Pediatric Pain
Mark Baccei, University of Cincinnati
Synaptic plasticity in adult spinal nociceptive circuits after neonatal tissue damage
Ruth Grunau, Univeristy of British Columbia
Pain in Preterm Infants: What Matters Most?
9:45-10:30 am
Session 5–Voltage-gated Channels in Pain
Chair: Rajesh Khanna
Theodore Cummins, Indiana University
Resurgent sodium currents in inherited and acquired pain syndromes
Rajesh Khanna, University of Arizona
Targeting trafficking of calcium and sodium channels with bifunctional peptides
Cheryl Stucky, Medical College of Wisconsin
Mechanosensitive currents in myelinated sensory neurons are sensitized following in vivo inflammation of muscle and skin
10:30-10:45 am
Break
10:45-11:45 am
Session 6–Optogenetic and Chemogenetic Modulation of Pain
Chair: Brian Davis
Rebecca Seal, University of Pittsburgh
A chemogenetic approach to define spinal cord circuits for pain
Brian Davis, University of Pittsburgh
Judging DREADDs for pain research
Junichi Hachisuka, University of Pittsburgh
Optogenetic probing of spinal microcircuits uncovers novel mechanisms underlying the amplification of pain and itch
Steven Prescott, University of Toronto
Optophysiological investigation of axonal excitability and coding
11:45-12:45 pm
Session 7–Gene Therapy for Chronic Pain
Chair: Carolyn Fairbanks
Andreas Beautler, Mayo Clinic
AAV Gene Therapy for Pain: Preclinical Translation from Rodent- to Large Animal Models
Karin N. Westlund-High, University of Kentucky
HSV-1 Vector Encoding the Human Preproenkephalin Gene for Treatment of Facial Pain in Mice
Carolyn Fairbanks, University of Minnesota
Reduction of neuropathic pain and opioid analgesic tolerance following expression of human arginine decarboxylase in rodents.
Shuanglin Hao, University of Miami
GAD67 mediated by HSV vectors for HIV-related neuropathic pain—Current Preclinical Studies
12:45-1:45 pm
Session 8–Emerging Therapeutic Targets for Pain
Chairs: Ru-Rong Ji, Kenneth Wild
Michael Jarvis, AbbVie
Cav3.2 calcium channel blocker in pain modulation
Wolfgang Liedtke, Duke University
Targeted Relief of Pain of cranial nerve V (trigeminal): TRPV4
Ru-Rong Ji, Duke University
Secreted miRNAs as novel pain mediators
Kenneth Wild, Amgen
TRPM8 antagonists as pain and migraine therapeutics: From Discovery to the clinic
2–6 pm
Optional Afternoon Activities for Spring Pain
2 pm
Spring Pain Golf Outing
Join your Spring Pain colleagues for an afternoon of golf at the Escena Golf Club in beautiful Palm Springs. Tee-time is 2:02 pm. Cost is $45 for person and $25 to rent clubs. Contact Michael Jankowski to reserve your spot. Space is limited. Taxi fares from the Renaissance Hotel to the golf course is about $12.
Wednesday, May 13
8-9 am
Session 9–Intrathecal Substance P-Saporin: From Idea to Therapy
Chair: Patrick Mantyh
Patrick Mantyh, University of Arizona
A very short introduction
Doug Lappi, Advanced Targeting Systems
Targeted killing of specific populations of spinal cord neurons to attenuate cancer pain: Molecular Neurosurgery
Tony Yaksh, University of California-San Diego
Intrathecal SP saporin-Preclinical safety on the road to the human and veterinary clinic
Carl Noe, University of Texas-Southwestern
Update on human clinical trials using SP-saporin
9-9:45 am
Session 10–Invertebrate models of pain and novel nociceptive Targets
Chair: Geoff Ganter
Michael Galko, University of Texas-MD Anderson
Modeling nociceptive hypersensitivity in Drosophila larvae
Daniel Cox, (Georgia State University
A novel Drosophila model of cold nociception
Geoff Ganter, University of New England
Modulation of nociception in the fly
9:45-10 am
Break
10-11 am
Session 11–Imaging Clinical Pain
Chair: Roger Fillingim
Richard Harris, University of Michigan
Neurochemical Correlates of Symptom Cluster Resolution: The Sleep–Pain Interface
Robert Coghill, Wake Forest University
Dynamic Spatial Tuning of Nociceptive Processing
Tor Wager, University of Colorado-Boulder
Cerebral modulation of pain independent of nociception
Sean Mackey, Stanford University
Perturbed Connectivity of the Amygdala and its Subregions with the Central Executive and Default Mode Networks in Chronic Pain
11-Noon
Session 12–Effects of pain on the reward pathway: Implications for Drug Abuse
Chairs: Catherine Cahill, José Morón-Concepción
Frank Porreca, University of Arizona
Evaluation of reward from pain relief
Neil Schwartz, University of California-San Francisco
The encoding of pain in reward circuitry
José Morón-Concepción, Columbia University
Inflammatory pain triggers an increase in opioid self-administration
Catherine Cahill, University of California-Irvine
Chronic pain modulates dopamine circuitry
Noon-1 pm
Session 13–GPCR targets
Chair: Todd Vanderah
Eric Nisenbaum, Eli Lilly
LY2491503, A Novel mGlu1 Antagonist for Chronic Pain: From Clone to Clinic
Derek Molliver, University of New England
Integration of G protein-coupled receptor signaling pathways
Nathan Jeske, University of Texas-San Antonio
Awakening a DORmant Receptor
George Wilcox, University of Minnesota
Alpha-2A adrenergic and delta opioid receptors act presynaptically to inhibit release of excitatory neurotransmitter from nociceptive afferent terminals
1 pm
Spring Pain Closing
APS Annual Scientific Meeting Begins
1-4:15 pm
Early Career Forum hosted by APS
4:30-6 pm
APS Welcome Reception
6:15-8:15 pm
APS and Spring Pain Clinical and Basic Science Data Blitz
For more information regarding Spring Pain sessions, visit www.springpainconference.com.
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