Notice of Intent to Publish an RFA for Tissue Chips to Model Nociception, Addiction, and Overdose
The National Center for Advancing Translational Sciences (NCATS) has released NOT-TR-19-007, a Notice of Intent to Publish a Funding Opportunity Announcement for Tissue Chips to Model Nociception, Addiction, and Overdose. This FOA is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative and will be intended to create and test devices that can model the mechanisms or effects of nociception/pain-relevant signaling, addiction, or opioid use disorders (OUDs), using human tissues in in vitro microphysiological systems (MPS), also known as “tissue chips” or “organs-on-chip”. The FOA will invite applications for development and validation of highly reproducible and translatable in vitro MPS models that can be utilized for preclinical efficacy studies by providing information on the discovery and validation of translatable biomarkers, development of standardized methods for preclinical efficacy testing, and definitive efficacy testing of candidate therapeutics using best practices and rigorous study design. Neural and non-neural tissue platform development and validation will be supported. The FOA is expected to be published in December 2018, with an expected application due date in February 2019.